BMS-708163 |cas 1146699-66-2 |Supplier|Price|Buy

DC Chemicals Supply:BMS-708163 ,cas 1146699-66-2, Cat No. DC3114, In stock

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Product name: BMS-708163, Synonym:　BMS708163,BMS 708163, Cat No. DC3114, Cas: 1146699-66-2, Chemical Name:(2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide, Molecular Formula: C20H17ClF4N4O4S, MW: 520.88

BMS-708163 Cas#1146699-66-2.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively.

Description of Avagacestat (BMS-708163): BMS-708163 (avagacestat) is an oral GSI designed for selective inhibition of Aβ synthesis currently in development for the treatment of mild to moderate and predementia AD. In addition to the desired effect on Aβ synthesis, GSIs affect Notch processing, which is thought to mediate some toxic adverse effects reported with this drug class. Avagacestat produced up to 190-fold greater selectivity for Aβ synthesis than Notch processing in preclinical studies and may therefore produce less toxic adverse events than other less selective compounds. Results from this single-ascending dose study suggest that avagacestat was tolerated at a single-dose range of 0.3 to 800 mg and suitable for further clinical development. (source: Clin Ther. 2012 Mar;34(3):654-67. Epub 2012 Feb 28.).

For the detailed information about the solubility of BMS-708163 in water, the solubility of BMS-708163 in DMSO, the solubility of BMS-708163 in PBS buffer, the animal experiment of BMS-708163,the in vivo and in vitro test of BMS-708163,the cell experiment of BMS-708163,the IC50 and EC50 of BMS-708163please contact DC Chemicals.