Compound 401 |cas 168425-64-7 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Compound 401 ,cas 168425-64-7, Cat No. DC2085, In stock

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Product name: Compound 401, Synonym:　Compound401, Cat No. DC2085, Cas: 168425-64-7, Chemical Name:N/A, Molecular Formula: C16H15N3O2, MW: 281.314

Compound 401 Cas#168425-64-7.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over FRAP (mTOR) (IC50 = 5.3 ?M).

Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over FRAP (mTOR) (IC50 = 5.3 ?M). Compound 401 exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Compound 401 has been shown to induce apoptosis and inhibit FRAP-dependent growth in TSC1-/- murine embryo fibroblasts.

For the detailed information about the solubility of Compound 401 in water, the solubility of Compound 401 in DMSO, the solubility of Compound 401 in PBS buffer, the animal experiment of Compound 401,the in vivo and in vitro test of Compound 401,the cell experiment of Compound 401,the IC50 and EC50 of Compound 401please contact DC Chemicals.