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Product name: Gefitinib (ZD1839), Synonym: ZD-1839,ZD 1839, Cat No. DC2103, Cas: 184475-35-2, Chemical Name:N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine, Molecular Formula: C22H24ClFN4O3, MW: 446.9
Gefitinib (ZD1839) Cas#184475-35-2.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
Description of gefitinib: Gefitinib is an anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. Gefitinib (INN) (Iressa) is a drug used in the treatment of certain types of cancer. Gefitinib is an EGFR inhibitor, like erlotinib, which interrupts a growth factor in cancer cells. It is marketed by AstraZeneca and Teva. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of Gefitinib (ZD1839) in water, the solubility of Gefitinib (ZD1839) in DMSO, the solubility of Gefitinib (ZD1839) in PBS buffer, the animal experiment of Gefitinib (ZD1839),the in vivo and in vitro test of Gefitinib (ZD1839),the cell experiment of Gefitinib (ZD1839),the IC50 and EC50 of Gefitinib (ZD1839)please contact DC Chemicals.
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