TDZD-8 |cas 327036-89-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: TDZD-8 ,cas 327036-89-5, Cat No. DC2067, In stock

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Product name: TDZD-8, Synonym:　TDZD8, TDZD 8, Cat No. DC2067, Cas: 327036-89-5, Chemical Name:1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-, Molecular Formula: C10H10N2O2S, MW: 222.26

TDZD-8 Cas#327036-89-5.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM.

Description of TDZD-8: TDZD-8 is a serine/threonine glycogen synthase kinase 3beta (GSK-3beta) inhibitor. GSK-3beta is abundant in the central nervous system, particularly in the hippocampus, and plays a pivotal role in the pathophysiology of a number of diseases, including neurodegeneration. TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. TDZD-8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes. Treatment of glioblastoma stem cells with TDZD-8 resulted in an inhibition of proliferation and self-renewal of these cells.

For the detailed information about the solubility of TDZD-8 in water, the solubility of TDZD-8 in DMSO, the solubility of TDZD-8 in PBS buffer, the animal experiment of TDZD-8,the in vivo and in vitro test of TDZD-8,the cell experiment of TDZD-8,the IC50 and EC50 of TDZD-8please contact DC Chemicals.