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Product name: Ku-0063794, Synonym: Ku0063794,Ku 0063794, Cat No. DC3101, Cas: 938440-64-3, Chemical Name:(5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol, Molecular Formula: C25H31N5O4, MW: 465.54
Ku-0063794 Cas#938440-64-3.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! KU-0063794 is a potent and highly specific mTOR inhibitor for both mTORC1 and mTORC2 with IC50 ~10 nM.
Description of KU0063794: Ku-0063794 inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3-kinases) at 1000-fold higher concentrations. Ku-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. Ku-0063794 also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). Ku-0063794 does not affect Thr308 phosphorylation in fibroblasts lacking essential mTORC2 subunits. Ku-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. Ku-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated. (source: Biochem J. 2009 Jun 12;421(1):29-42.).
For the detailed information about the solubility of Ku-0063794 in water, the solubility of Ku-0063794 in DMSO, the solubility of Ku-0063794 in PBS buffer, the animal experiment of Ku-0063794,the in vivo and in vitro test of Ku-0063794,the cell experiment of Ku-0063794,the IC50 and EC50 of Ku-0063794please contact DC Chemicals.
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