MRK003 |cas 623165-93-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: MRK003 ,cas 623165-93-5, Cat No. DC3122, In stock

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Product name: MRK003, Synonym:　MRK 003,MRK-003, Cat No. DC3122, Cas: 623165-93-5, Chemical Name:N/A, Molecular Formula: C25H31F6N3O2S, MW: 551.59

MRK003 Cas#623165-93-5.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma.

Description of MRK003:  MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. MRK003 treatment induced caspase-dependent apoptosis and inhibited proliferation of MM and NHL cell lines and patient cells. Examination of signaling events after treatment showed time-dependent decrease in levels of the notch intracellular domain, Hes1 and c-Myc. MRK003 downregulated cyclin D1, Bcl-Xl and Xiap levels in NHL cells and p21, Bcl-2 and Bcl-Xl in MM cells. In addition, MRK003 caused an upregulation of pAkt, indicating crosstalk with the PI3K/Akt pathway. (source: Leukemia (2012) 26, 340–348; doi:10.1038/leu.2011.192).

For the detailed information about the solubility of MRK003 in water, the solubility of MRK003 in DMSO, the solubility of MRK003 in PBS buffer, the animal experiment of MRK003,the in vivo and in vitro test of MRK003,the cell experiment of MRK003,the IC50 and EC50 of MRK003please contact DC Chemicals.