Lovastatin (MK-803) |cas 75330-75-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Lovastatin (MK-803) ,cas 75330-75-5, Cat No. DC2105, In stock

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Product name: Lovastatin (MK-803), Synonym:　MK803, Lovastatin (MK 803), Cat No. DC2105, Cas: 75330-75-5, Chemical Name:N/A, Molecular Formula: C24H36O5, MW: 404.54

Lovastatin (MK-803) Cas#75330-75-5.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent).

Lovastatin is a statin natural product isolated from numerous sources including the Pleurotus ostreatus oyster mushroom, demonstrating hypocholesterolemic and antiproliferative properties. Lovastatin inhibits HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), blocking the enzyme-catalyzed transformation of 3-hydroxy-3-methylglutaryl CoA into mevalonate. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts cholesterol synthesis, leading to a reduction of circulating low-density lipoproteins. Lovastatin demonstrates arrest of the cell cycle at the G1 phase in bladder carcinoma T24 cells expressing activated p21ras oncoprotein - the posttranslational isoprenylation of the p21ras with mevalonate is crucial for translocation and membrane adhesion of the protein, and blockade of this modification by Lovastatin-induced depletion of cellular mevalonate leads to suspension of cell progress. The signaling activity of epidermal growth factor (EGF) and insulin-like growth factor (IGF-I) are similarly affected by impairment of mevalonate-dependent protein prenylation. Induction of apoptosis by Lovastatin in malignant mesothelioma cells is also ascribed to the inhibition of mevalonate synthesis and posttranslational protein modifications. Lovastatin is a substrate of CYP and Mdr-1.

For the detailed information about the solubility of Lovastatin (MK-803) in water, the solubility of Lovastatin (MK-803) in DMSO, the solubility of Lovastatin (MK-803) in PBS buffer, the animal experiment of Lovastatin (MK-803),the in vivo and in vitro test of Lovastatin (MK-803),the cell experiment of Lovastatin (MK-803),the IC50 and EC50 of Lovastatin (MK-803)please contact DC Chemicals.