Dovitinib (TKI-258, CHIR-258) |cas 915769-50-5 |Supplier|Price|Buy

DC Chemicals Supply: Dovitinib (TKI-258, CHIR-258) ,cas 915769-50-5, Cat No. DC3141, In stock

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Product name: Dovitinib (TKI-258,CHIR-258), Synonym:　TKI258,CHIR258,Dovitinib (TKI 258,CHIR 258), Cat No. DC3141, Cas: 915769-50-5, Chemical Name:N/A, Molecular Formula: C21H21FN6O.C3H6O3.H2O, MW: 500.53

Dovitinib (TKI-258,CHIR-258) Cas#915769-50-5.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.

Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor.

Dovitinib inhibited proliferation of ZNF198-FGFR1 and BCR-FGFR1 transformed Ba/F3 cells with IC50 values of 150 nM and 90 nM, respectively. The phosphorylation of each fusion gene, ERK, and STAT5 was inhibited as well at the same time. Dovitinib also inhibited proliferation of the FGFR1OP2-FGFR1-positive KG1 and KG1A cell lines and induced apoptosis. Furthermore, dovitinib significantly inhibited the growth of primary cells from 8p11 myeloproliferative syndrome (EMS) patients dose-dependently.For the detailed information about the solubility of Dovitinib (TKI-258, CHIR-258) in water, the solubility of Dovitinib (TKI-258, CHIR-258) in DMSO, the solubility of Dovitinib (TKI-258, CHIR-258) in PBS buffer, the animal experiment of Dovitinib (TKI-258, CHIR-258),the in vivo and in vitro test of Dovitinib (TKI-258, CHIR-258),the cell experiment of Dovitinib (TKI-258, CHIR-258),the IC50 and EC50 of Dovitinib (TKI-258, CHIR-258)please contact DC Chemicals.