DC Chemials Supply: A-674563 supplier,cas 552325-73-2, Cat No. DC5163, In stock
Contact: website: www.dcchemicals.com
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Tel: +86-21-61454686;Fax:+86-21-61642878；
Tel: +86-21-61454686;Fax:+86-21-61642878；
Product name: A-674563, Synonym: A-674563;
A-674563,cas 552325-73-2, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively.
A-674563 is a potent selective Akt1 (Protein Kinase B) inhibitor (IC50 = 14 nM). A-674563 also shows inhibitory activity against PKA and Cdk2 (IC50’s: PKA = 16 nM; Cdk2 = 46 nM). A-674563 has been shown to have a significant effect on depolarization of purkinje fiber in an in vitro assay, and severe CV toxicity (e.g. hypotension) in vivo. The X-ray structure of A-674563 bound to protein kinase A, which exhibits 80% homology with Akt in the kinase domain, suggested the phenyl group is not tightly bound in the ligand-protein complex. The Akt inhibitor A-674563 displayed proliferation of tumor cells (EC50: 0.4 μM). When given in combination, A-674563 enhanced the efficacy of paclitaxel in a PC-3 xenograft model.
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