Nutlin-3 |cas 548472-68-0 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Nutlin-3 ,cas 548472-68-0, Cat No. DC3125, In stock

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Product name: Nutlin-3, Synonym:　Nutlin3,Nutlin 3, Cat No. DC3125, Cas: 548472-68-0, Chemical Name:N/A, Molecular Formula: C30H30Cl2N4O4, MW: 581.5

Nutlin-3 Cas#548472-68-0.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals!  RO5045337, also known as R7112, RG7112,  is a MDM2 antagonist with potential antineoplastic activity.

Description of RO5045337: RO5045337, also known as R7112, RG7112,  is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).For the detailed information about the solubility of Nutlin-3 in water, the solubility of Nutlin-3 in DMSO, the solubility of Nutlin-3 in PBS buffer, the animal experiment of Nutlin-3,the in vivo and in vitro test of Nutlin-3,the cell experiment of Nutlin-3,the IC50 and EC50 of Nutlin-3please contact DC Chemicals.