NVP-BEZ235 |cas 915019-65-7 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: NVP-BEZ235 ,cas 915019-65-7, Cat No. DC3136, In stock

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-61454686;Fax:+86-21-61642643；

Product name: NVP-BEZ235, Synonym:　BEZ235, Cat No. DC3136, Cas: 915019-65-7, Chemical Name:2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile, Molecular Formula: C30H23N5O, MW: 469.55

NVP-BEZ235 Cas#915019-65-7.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.

Description of BEZ235: BEZ235 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BEZ235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

For the detailed information about the solubility of NVP-BEZ235 in water, the solubility of NVP-BEZ235 in DMSO, the solubility of NVP-BEZ235 in PBS buffer, the animal experiment of NVP-BEZ235,the in vivo and in vitro test of NVP-BEZ235,the cell experiment of NVP-BEZ235,the IC50 and EC50 of NVP-BEZ235please contact DC Chemicals.