Sunitinib base |cas 557795-19-4 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Sunitinib base,cas 557795-19-4, Cat No. DC3145, In stock

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Product name: Sunitinib base, Synonym:　SU-11248,SU11248, Cat No. DC3145, Cas: 557795-19-4, Chemical Name:(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide ,(S)-2-hydroxysuccinic acid, Molecular Formula: C22H27FN4O2.C4H6O5, MW: 532.56

Sunitinib base Cas#557795-19-4.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Description of Sunitinib malate: Sunitinib malate, also known as SU11248, is the orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

For the detailed information about the solubility of Sunitinib base in water, the solubility of Sunitinib base in DMSO, the solubility of Sunitinib base in PBS buffer, the animal experiment of Sunitinib base,the in vivo and in vitro test of Sunitinib base,the cell experiment of Sunitinib base,the IC50 and EC50 of Sunitinib baseplease contact DC Chemicals.