Verdinexor (KPT-335)|cas 1392136-43-4|DC Chemicals

Verdinexor (KPT-335)|cas 1392136-43-4|DC Chemicals

Verdinexor (KPT-335) is an orally bioavailable, selective XPO1/CRM1 inhibitor.

Product Name: Verdinexor (KPT-335) |Catalog Number:  DC8429 | cas: 1392136-43-4 | Other names: KPT-335,KPT 335,KPT335 | Chemical name：(2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]- 2-propenoic acid-2-(2-pyridinyl)hydrazide | Molecule Formula: C18H12F6N6O | MW: 442.32

Verdinexor inhibits the viability of Jurkat, OCI-Ly3, OCI-Ly10, and CLBL1 cells with IC50 of 0.3 nM, 2.1 nM, 41.8 nM, and 8.5 nM, respectively. KPT-335 also induces apoptosis in CLBL1 cells and primary canine DLBCL cells that express XPO1 and SINE. [1] Verdinexor potently and selectively inhibits vRNP export and effectively inhibits the replication of various influenza virus A and B strains, including pandemic H1N1 virus, highly pathogenic H5N1 avian influenza virus, and the recently emerged H7N9 strain. [2]Verdinexor (25 mg/kg twice daily, p.o.) reduces proinflammatory cytokine expression in the lung, produces in vivo antiviral activity by reducing lung virus titers, and thus reduces pulmonary disease pathogenesis and death associated with lethal influenza A virus challenge. [2] In autosomal-dominant polycystic kidney disease model, Verdinexor (5 mg/kg, i.p.) attenuates cyst growth via inhibition of XPO1.

For research and scientific purpose only, not for human use.