STF-31|STF31|GLUT1 inhibitor|DC Chemicals

STF-31|STF31|GLUT1 inhibitor|DC Chemicals

STF-31 is an inhibitor of GLUT1 (IC50 = ~1 µM) that blocks glucose uptake.

Product Name: STF-31 |Catalog Number:  DC8359 | cas: 724741-75-7 | Other names: STF31,STF 31 | Chemical name：4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-benzamide | Molecule Formula: C23H25N3O3S | MW: 423.5

STF-31 is an inhibitor of GLUT1 (IC50 = ~1 µM) that blocks glucose uptake.It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress GLUT1.Although STF-31 binds GLUT1, suggesting a direct effect, STF-31 also inhibits nicotinamide phosphoribosyltransferase, an enzyme that induces GLUT1 expression. STF-31 is also toxic to human pluripotent stem cells (hPSCs) and can be used to selectively eliminate hPSCs from mixed cultures.

For research and scientific purpose only, not for human use.