LY3009120|LY-3009120|Raf inhibitor|In stock|DC Chemicals

LY3009120|LY-3009120|Raf inhibitor|In stock|DC Chemicals
LY3009120 is a potent and selective pan-RAF inhibitor with potential anticancer activity.

Product Name: LY3009120 |Catalog Number:  DC8344 | cas: 1454682-72-4 | Other names: LY3009120; LY-3009120; LY 3009120; DP-4978; DP 4978; DP4978 | Chemical name：1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea | Molecule Formula: C23H29FN6O | MW: 424.5

LY3009120, also known as DP-4978, is  potent and selective pan-RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells. LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas.  LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in vitro, and exhibits anti-tumor activity in multiple xenograft models carrying mutations in BRaf, NRas or KRas. LY3009120 is a potentially best-in-class inhibitor of three Raf isoforms and Raf dimer, with activity against tumor cells with BRaf, NRas or KRas mutations, as well as melanoma cells with acquired resistance to current BRaf therapies. These unique features support investigation of LY3009120 in clinical studies.

For research and scientific purpose only, not for human use.