Sodium Tauroursodeoxycholate (TUDC)|cas 35807-85-3|DC Chemicals

Sodium Tauroursodeoxycholate (TUDC)|cas 35807-85-3|DC Chemicals

Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.

Product Name: Sodium Tauroursodeoxycholate (TUDC) |Catalog Number:  DC8384 | cas: 35807-85-3 | Other names:  | Chemical name：sodium 2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonate | Molecule Formula: C26H44NNaO6S | MW: 521.69

In vitro, Tauroursodeoxycholate shows protective and reversing effects on 17βEG-induced impairment of the cVA-of-CLF. [1] In Mz-ChA-1 cholangiocarcinoma cells, Tauroursodeoxycholate inhibits cell growth via Ca2+-, PKC-, and MAPK-dependent pathways. [3] In isolated rat hepatocytes, Tauroursodeoxycholate inhibits bile acid-Induced Apoptosis via a β1-integrin-mediated formation of cAMP. [4]In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2]

For research and scientific purpose only, not for human use.