STF-083010|cas 307543-71-1|DC Chemicals

STF-083010|cas 307543-71-1|DC Chemicals

STF-083010 is a specific IRE1α endonuclease inhibitor.

Product Name: STF-083010 |Catalog Number:  DC8413 | cas: 307543-71-1 | Other names: STF-083010,STF083010,STF 083010 | Chemical name：(E)-N-((2-hydroxynaphthalen-1-yl)methylene)thiophene-2-sulfonamide | Molecule Formula: C15H11NO3S2 | MW: 317.38

In RPMI 8226, MM.1S, and MM.1R MM cell lines, STF-083010 exhibits cytostatic and cytotoxic activity in a dose and time dependent manner. [1] [2] In MiaPaCa2, Panc0403, and SU8686 cell lines, STF-083010 inhibits XBP1 splicing and blocks IRE1α's endonuclease activity without affecting its kinase activity. [1] In Eμ-TCL1 CLL cells, STF-083010 exhibits about 70% growth inhibition after 3 days culture. In MEC1 and MEC2 cells, STF-083010 produces 20% growth inhibition in 48 h. WaC3 cells respond to treatments with STF-083010 with gradually decreased growth. [3]In human multiple myeloma (MM) xenografts model, STF-083010 (i.p., 30 mg/kg) significantly inhibits the growth of tumor.

For research and scientific purpose only, not for human use.