AGK2|cas 304896-28-4|DC Chemicals

AGK2|cas 304896-28-4|DC Chemicals

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM.

Product Name: AGK2 |Catalog Number:  DC8437 | cas: 304896-28-4 | Other names: AGK2,AGK-2,AGK 2 | Chemical name：2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide | Molecule Formula: C23H13Cl2N3O2 | MW: 434.27

In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3]In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation.

For research and scientific purpose only, not for human use.