Epacadostat (INCB024360)|cas 1204669-58-8|DC Chemicals

Epacadostat (INCB024360)|cas 1204669-58-8|DC Chemicals

Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. Phase 2.

Product Name: Epacadostat (INCB024360) |Catalog Number:  DC8389 | cas: 1204669-58-8 | Other names: INCB024360,INCB-024360,INCB 024360 | Chemical name：[C(Z)]-4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide | Molecule Formula: C11H13BrFN7O4S | MW: 438.23

In IFN-γ–treated human HeLa cells, INCB024360 potently inhibits kynurenine production. INCB024360 also promotes T and natural killer (NK)-cell growth, increases IFN-gamma production, and reduces conversion to regulatory T (T(reg))-like cells. [1INCB024360 (100 mg/kg, p.o.), via IDO1 inhibition, suppresses kyn generation and tumor growth in immunocompetent, but not immunodeficient, mice. [1] In mice bearing CT26 colon carcinoma, INCB024360 (100 mg/kg, p.o.) also inhibits the growth of IDO-expressing tumors by reducing kynurenine.

For research and scientific purpose only, not for human use.