JH-II-127|LRRK2 inhibitor|DC Chemicals

JH-II-127|LRRK2 inhibitor|DC Chemicals

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.

Product Name: JH-II-127 |Catalog Number:  DC8379 | cas: 1700693-08-8 | Other names: 2-anilino-4-methylamino-5-chloropyrrolopyrimidine,JH-II127,JH-II 127 | Chemical name：2-anilino-4-methylamino-5-chloropyrrolopyrimidine | Molecule Formula: C19H21ClN6O3 | MW: 416.86

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor,of both wild-type and G2019S mutant LRRK2.JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 μM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg.

For research and scientific purpose only, not for human use.