EW-7197|EW-7197|ALK5 inhibitor|DC Chemicals

EW-7197|EW-7197|ALK5 inhibitor|DC Chemicals
EW-7197  is a potent ALK5 inhibitor. EW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy.

Product Name: EW-7197 |Catalog Number:  DC8342 | cas: 1352608-82-2(EW-7197); 1352610-25-3 (EW-7197 HCl salt) | Other names: EW-7197，EW 7197，EW7197 | Chemical name：N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline | Molecule Formula: C22H18FN7 | MW: 399.42

EW-7197  is a potent ALK5 inhibitor. EW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy. EW-7197 inhibits TGF-β/Smad signaling. EW-7197 abrogates TGF-β1-induced tumor cell migration and invasion. EW-7197 inhibits breast cancer metastasis to the lung.EW-7197 prolongs the life span of BALB/c 4T1 mice via inhibition of EMT. EW-7197 inhibits metastasis and enhances the activity of cytotoxic T lymphocytes
(CTLs) in 4T1 orthotopic grafted mice.

For research and scientific purpose only, not for human use.