AZD8186|AZD-8186|PI3Kβand PI3Kδ inhibitor|DC Chemicals

AZD8186|AZD-8186|PI3Kβand PI3Kδ inhibitor|DC Chemicals

AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity.

Product Name: AZD8186 |Catalog Number:  DC8380 | cas: 1627494-13-6 | Other names: AZD8186,AZD-8186,AZD 8186 | Chemical name：(R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide | Molecule Formula: C24H25F2N3O4 | MW: 457.47

AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials.

For research and scientific purpose only, not for human use.