L-779,450|L-779450|RAF inhibitor|DC Chemicals

L-779,450|L-779450|RAF inhibitor|DC Chemicals

L-779,450 is a potent, ATP-competitive Raf (Raf kinase) inhibitor (IC50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.

Product Name: L-779,450 |Catalog Number:  DC8362 | cas: 303727-31-3 | Other names:  | Chemical name：2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol | Molecule Formula: C20H14ClN3O | MW: 347.8

Potent, ATP-competitive Raf kinase inhibitor (IC50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.

For research and scientific purpose only, not for human use.