Dyngo-4a|cas 1256493-34-1|DC Chemicals

Dyngo-4a|cas 1256493-34-1|DC Chemicals

Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1 μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively.

Product Name: Dyngo-4a |Catalog Number:  DC8396 | cas: 1256493-34-1 | Other names:  | Chemical name：(E)-N'-(2,4,5-trihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide | Molecule Formula: C18H14N2O5 | MW: 338.31

Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC₅₀ of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. [1] In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. [2] In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin.

For research and scientific purpose only, not for human use.