Disodium (R)-2-Hydroxyglutarate|cas 103404-90-6|DC Chemicals

Disodium (R)-2-Hydroxyglutarate|cas 103404-90-6|DC Chemicals

Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.

Product Name: Disodium (R)-2-Hydroxyglutarate |Catalog Number:  DC8385 | cas: 103404-90-6 | Other names:  | Chemical name：sodium (R)-2-hydroxypentanedioate | Molecule Formula: C5H6Na2O5 | MW: 192.08

In U-87MG cells, (R)-2-Hydroxyglutarate acts as weak antagonists of α-KG to inhibit α-KG-dependent histone demethylases and increases dimethylation on both H3K9 and H3K79. [1] Besides, (R)-2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling, and thus causes growth arrest and tumor cell killing. [2]

For research and scientific purpose only, not for human use.