ONO-4059(ONO-WG-307)|Btk/Tec inhibitor|DC Chemicals

ONO-4059(ONO-WG-307)|Btk/Tec inhibitor|DC Chemicals

ONO-4059 is a novel Small Molecule Dual Inhibitor Of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase.

Product Name: ONO-4059 |Catalog Number:  DC8358 | cas: 1351635-67-0 | Other names: ONO-4059,ONO 4059,ONO4059 | Chemical name：(S)-9-(1-acryloylpiperidin-3-yl)-6-amino-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one | Molecule Formula: C25H24N6O3 | MW: 456.5

ONO-4059 is a highly potent and dual oral Btk/Tec inhibitor with an IC50 in the sub-nmol/L range. Previous studies with ONO-4059 demonstrated that ONO-4059 significantly inhibits the macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL)-driven osteoclast defferentiation. The treatment with ONO-4059 also resulted in a dose-dependent inhibition of arthritis severity and bone damage in a mouse collagen induced arthritis (CIA) model (ACR 2012).Btk and Tec are required for osteoclast differentiation and activation based on the genetic evidence obtained from Btk and Tec double deficient mice. Dual Btk/Tec inhibitor, ONO-4059 may be a novel therapeutic target for RA to suppress bone erosion and inflammation.

For research and scientific purpose only, not for human use.