JZL-195| FAAH and MAGL inhibitor|DC Chemicals

JZL-195| FAAH and MAGL inhibitor|DC Chemicals

JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50 = 2 and 4 nM, respectively).

Product Name: JZL-195 |Catalog Number:  DC8352 | cas: 1210004-12-8 | Other names: JZL-195,JZL 195,JZL195 | Chemical name： | Molecule Formula: C24H23N3O5 | MW: 433.5

JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50 = 2 and 4 nM, respectively).It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 and JZL 184, respectively.Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.

For research and scientific purpose only, not for human use.