Oltipraz|cas 64224-21-1|DC Chemicals

Oltipraz|cas 64224-21-1|DC Chemicals

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.

Product Name: Oltipraz |Catalog Number:  DC8390 | cas: 64224-21-1 | Other names:  | Chemical name：4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione | Molecule Formula: C8H6N2S3 | MW: 226.34

Oltipraz, as a chemoprotective agent, induces Phase II detoxification enzyme activity in a Nrf2-dependent manner. [1] In human HT29 colon cancer cells, oltipraz inhibits the induction of HIF-1α by insulin, hypoxia or CoCl2 by significantly accelerating degradation of HIF-1α protein. [2]Oltipraz (500 mg/kg, p.o.) significantly reduces multiplicity of gastric neoplasia in wild-type mice by 55%, but has no effect on tumor burden in nrf2-deficient mice. [1] In BALB/c nude mice transplanted with HCT116 cells, Oltipraz (200 mg/kg, p.o.) inhibits tumor growth and angiogenesis via inhibition of HIF-1α. [2] In rats on a CDAA diet, Oltipraz attenuate the progression of nonalcoholic steatohepatitis-related fibrosis.

For research and scientific purpose only, not for human use.