Dibutyryl-cAMP (Bucladesine)|cas 16980-89-5|DC Chemicals

Dibutyryl-cAMP (Bucladesine)|cas 16980-89-5|DC Chemicals

Dibutyryl-cAMP (Bucladesine) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP.

Product Name: Dibutyryl-cAMP (Bucladesine) |Catalog Number:  DC8394 | cas: 16980-89-5 | Other names:  | Chemical name：N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate) 2'-butanoate-adenosine,sodium salt (1?) | Molecule Formula: C18H23N5NaO8P | MW: 491.37

Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation. [1] In cultured rat hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity. [2] Dibutyryl-cAMP also suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation. [3]In a mouse model, bucladesine (600 nM/mouse, i.p.) reverses zinc chloride- and lead acetate-induced avoidance memory retention impairments.

For research and scientific purpose only, not for human use.