Dp44mT|cas 152095-12-0|DC Chemicals

Dp44mT|cas 152095-12-0|DC Chemicals

Dp44mT is a potent iron chelator, which shows selective antitumor activity.

Product Name: Dp44mT |Catalog Number:  DC8383 | cas: 152095-12-0 | Other names:  | Chemical name：2-(di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide | Molecule Formula: C14H15N5S | MW: 285.37

Dp44mT shows pronounced antiproliferative effects in SK-N-MC, SK-Mel-28, and MCF-7 cells with IC50 of 30 nM, 60 nM, and 60 nM, respectively, while no effects on normal MRC-5 fibroblasts. Dp44mT inhibits cellular Fe uptake from Fe-Tf in SK-N-MC neuroepithelioma and M109 cells, and induces cell apoptosis. [1] In MDA-MB-231 cells, Dp44mT specifically targets topoisomerase topo2α, and thus causes DNA damage. [2] Dp44mT, as a Pgp substrate, also overcomes multidrug resistance by the hijacking of lysosomal P-glycoprotein (Pgp). [3]In CD2F1 mice bearing M109 tumors, Dp44mT (0.4 mg/kg, i.v.) inhibits tumor growth in a dose-dependent manner. [1]

For research and scientific purpose only, not for human use.