Cyclo(RGDyK)|cas 250612-42-1|DC Chemicals

Cyclo(RGDyK)|cas 250612-42-1|DC Chemicals

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

Product Name: Cyclo(RGDyK) |Catalog Number:  DC8399 | cas: 250612-42-1 | Other names:  | Chemical name：cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl), 2,2,2-trifluoroacetate (1:2) | Molecule Formula: C31H43F6N9O12 | MW: 847.72

Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. [1] Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM). [2]In apoE−/− mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery.

For research and scientific purpose only, not for human use.