BQ-123|cas 136553-81-6|DC Chemicals

BQ-123|cas 136553-81-6|DC Chemicals

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

Product Name: BQ-123 |Catalog Number:  DC8392 | cas: 136553-81-6 | Other names: BQ-123,BQ 123,BQ123 | Chemical name：cyclo-Asp-Pro-Val-Leu-Trp | Molecule Formula: C31H42N6O7 | MW: 610.7

In porcine aortic vascular smooth muscle cells, BQ-123 selectively inhibits ETA-mediated contraction. [1] In rat vascular smooth muscle cells, BQ-123 inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis. [2]In rats, BQ-123 (1 mg/kg, i.v.) ameliorates myocardial ischemic-reperfusion injury. [3] In rats with pentylenetetrazole (PTZ)-induced tonic-clonic seizures, BQ-123 (3 mg/kg, i.v.) potently impedes the formation and spread of seizure. [4] In pregnant C57BL/6 mice, BQ-123 (6.7 mg/kg, i.p.) prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.

For research and scientific purpose only, not for human use.