SB-334867|cas 792173-99-0|DC Chemicals

SB-334867|cas 792173-99-0|DC Chemicals

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

Product Name: SB-334867 |Catalog Number:  DC8419 | cas: 792173-99-0 | Other names: SB334867,SB 334867,SB-334867 | Chemical name：1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea | Molecule Formula: C17H13N5O2 | MW: 319.32

In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response. [1]In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. [2] SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. [3] SB-334867 also inhibits the development of morphine analgesic tolerance in rats.

For research and scientific purpose only, not for human use.