BRD7552|cas 1137359-47-7|DC Chemicals

BRD7552|cas 1137359-47-7|DC Chemicals

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.

Product Name: BRD7552 |Catalog Number:  DC8409 | cas: 1137359-47-7 | Other names: BRD 7552,BRD-7552,BRD7552 | Chemical name：ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate | Molecule Formula: C33H33N3O15 | MW: 711.63

BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression.

For research and scientific purpose only, not for human use.