PF-04418948,PF04418948|EP2 receptor inhibitor|DC Chemicals

PF-04418948,PF04418948|EP2 receptor inhibitor|DC Chemicals

PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).

Product Name: PF-04418948 |Catalog Number:  DC8353 | cas: 1078166-57-0 | Other names: PF-04418948,PF04418948,PF 04418948 | Chemical name：1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid | Molecule Formula: C23H20FNO5 | MW: 409.41

Potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).

For research and scientific purpose only, not for human use.