Smoothened Agonist (SAG) HCl|cas 912545-86-9(free base)|DC Chemicals

Smoothened Agonist (SAG) HCl|cas 912545-86-9(free base)|DC Chemicals

Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.

Product Name: Smoothened Agonist (SAG) HCl |Catalog Number:  DC8391 | cas: 912545-86-9(free base) | Other names:  | Chemical name：N-(3-(pyridin-4-yl)benzyl)-3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide hydrochloride | Molecule Formula: C28H29Cl2N3OS | MW: 526.52

SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. [1] SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. [2] SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells. [3]In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities.

For research and scientific purpose only, not for human use.