Losartan carboxylic acid|EXP-3174|DC Chemicals

Losartan carboxylic acid|EXP-3174|DC Chemicals

Losartan carboxylic acid is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver.

Product Name: Losartan Carboxylic Acid |Catalog Number:  DC8356 | cas: 124750-92-1 | Other names: E-3174，EXP-3174,E 3174，EXP 3174,E3174，EXP3174 | Chemical name：2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid | Molecule Formula: C22H21ClN6O2 | MW: 436.89

Losartan carboxylic acid is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver.Like the parent compound, losartan carboxylic acid is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation.When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan.8 However, the metabolite has very low oral bioavailability.Losartan, but not its metabolite, inhibits platelet aggregation in vitro.

For research and scientific purpose only, not for human use.