Contact:sales@dcchemicals.com, order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-61454686;Fax:+86-21-61642470
website: www.dcchemicals.com
Product name: Ruxolitinib (INCB018424), Synonym: Ruxolitinib, Cat No. DC4230, Cas: 941678-49-5, Chemical Name:N/A, Molecular Formula: C17H18N6, MW: 306.371
Ruxolitinib (INCB018424) Cas#941678-49-5.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Ruxolitinib is a potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively and is relatively less selective for JAK3 (IC50 = 322 nM).It can block interleukin-6 (IL-6) signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM).In primary cultures, ruxolitinib preferentially suppresses erythroid progenitor colony formation from JAK2V617F+ polycythemia vera patients (IC50 = 67 nM) versus healthy donors (IC50 > 400 nM).In a mouse model of JAK2V617F+ MPN, 90 mg/kg ruxolitinib reduced splenomegaly, decreased circulating levels of IL-6 and TNF-α, eliminated neoplastic cells, and prolonged survival of the treated animals.
For the detailed information about the solubility of Ruxolitinib (INCB018424) in water, the solubility of Ruxolitinib (INCB018424) in DMSO, the solubility of Ruxolitinib (INCB018424) in PBS buffer, the animal experiment of Ruxolitinib (INCB018424),the in vivo and in vitro test of Ruxolitinib (INCB018424),the cell experiment of Ruxolitinib (INCB018424),the IC50 and EC50 of Ruxolitinib (INCB018424)please contact DC Chemicals.
没有评论:
发表评论