DC Chemicals Supply: NVP-AEW541 ,cas 475489-16-8, Cat No. DC4174, In stock
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Product name: NVP-AEW541, Synonym: AEW541,NVP AEW541, Cat No. DC4174, Cas: 475489-16-8, Chemical Name:7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Molecular Formula: C27H29N5O, MW: 439.55
NVP-AEW541 Cas#475489-16-8.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM.
NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative small molecular weight kinase inhibitor of the IGF-IR, capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. As expected for a specific IGF-IR kinase inhibitor, NVP-AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. In vivo, this orally bioavailable compound inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. Thus, NVP-AEW541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application. (Source: García-Echeverría C, Pearson MA, Marti A, Meyer T, Mestan J, Zimmermann J, Gao J, Brueggen J, Capraro HG, Cozens R, Evans DB, Fabbro D, Furet P, Porta DG, Liebetanz J, Martiny-Baron G, Ruetz S, Hofmann F. Cancer Cell. 2004 Mar;5(3):231-9.)
For the detailed information about the solubility of NVP-AEW541 in water, the solubility of NVP-AEW541 in DMSO, the solubility of NVP-AEW541 in PBS buffer, the animal experiment of NVP-AEW541 ,the in vivo and in vitro test of NVP-AEW541 ,the cell experiment of NVP-AEW541 ,the IC50 and EC50 of NVP-AEW541 please contact DC Chemicals.
For the detailed information about the solubility of NVP-AEW541 in water, the solubility of NVP-AEW541 in DMSO, the solubility of NVP-AEW541 in PBS buffer, the animal experiment of NVP-AEW541 ,the in vivo and in vitro test of NVP-AEW541 ,the cell experiment of NVP-AEW541 ,the IC50 and EC50 of NVP-AEW541 please contact DC Chemicals.
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