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Product name: LDK378 (ALK1 inhibitor), Synonym: LDK-378; LDK378., Cat No. DC5167, Cas: 1032900-25-6, Chemical Name:5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, Molecular Formula: C28H36ClN5O3S, MW: 558.14
LDK378 (ALK1 inhibitor),cas 1032900-25-6, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. LDK378 is a highly selective ALK inhibitor with IC50 of 2 nM.
LDK378 is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib.
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