ML-7 Hydrochloride |cas 110448-33-4 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: ML-7 Hydrochloride ,cas 110448-33-4, Cat No. DC2052, In stock

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Product name: ML-7 Hydrochloride, Synonym:　ML7, Cat No. DC2052, Cas: 110448-33-4, Chemical Name:N/A, Molecular Formula: C15H18ClIN2O2S, MW: 452.74

ML-7 Hydrochloride Cas#110448-33-4.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! ML-7 Hydrochloride is a selective inhibitor of myosin light chain kinase (MLCK) (Ki = 0.3 μM).

Selective inhibitor of myosin light chain kinase (MLCK) (Ki = 0.3 μM). Exhibits more potent inhibition than the parent compound ML 9 hydrochloride. Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs.

For the detailed information about the solubility of ML-7 Hydrochloride in water, the solubility of ML-7 Hydrochloride in DMSO, the solubility of ML-7 Hydrochloride in PBS buffer, the animal experiment of ML-7 Hydrochloride,the in vivo and in vitro test of ML-7 Hydrochloride,the cell experiment of ML-7 Hydrochloride,the IC50 and EC50 of ML-7 Hydrochlorideplease contact DC Chemicals.

PD-173074 |cas 219580-11-7 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PD-173074 ,cas 219580-11-7, Cat No. DC2054, In stock

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Product name: PD-173074, Synonym:　PD173074, PD 173074, Cat No. DC2054, Cas: 219580-11-7, Chemical Name:1-tert-butyl-3-(2-(4-(diethylamino)butylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea, Molecular Formula: C28H41N7O3, MW: 523.67

PD-173074 Cas#219580-11-7.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.

Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.

For the detailed information about the solubility of PD-173074 in water, the solubility of PD-173074 in DMSO, the solubility of PD-173074 in PBS buffer, the animal experiment of PD-173074,the in vivo and in vitro test of PD-173074,the cell experiment of PD-173074,the IC50 and EC50 of PD-173074please contact DC Chemicals.

Droxidopa (L-DOPS, SM-5688) |cas 23651-95-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Droxidopa (L-DOPS, SM-5688)  ,cas 23651-95-8, Cat No. DC2056, In stock

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Product name: Droxidopa (L-DOPS,SM-5688), Synonym:　SM5688, Droxidopa (L DOPS,SM 5688), Cat No. DC2056, Cas: 23651-95-8, Chemical Name:(2S,3R)-3-(3,4-Dihydroxyphenyl)-2-amino-3-hydroxypropanoic acid, Molecular Formula: C9H11NO5, MW: 213.19

Droxidopa (L-DOPS,SM-5688) Cas#23651-95-8.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

L-DOPS (L-threo-dihydroxyphenylserine; Droxidopa; SM-5688) is a psychoactive drug and synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).[1] Unlike norepinephrine and epinephrine themselves, L-DOPS is capable of crossing the protective blood–brain barrier (BBB).[1]

For the detailed information about the solubility of Droxidopa (L-DOPS, SM-5688)  in water, the solubility of Droxidopa (L-DOPS, SM-5688)  in DMSO, the solubility of Droxidopa (L-DOPS, SM-5688)  in PBS buffer, the animal experiment of Droxidopa (L-DOPS, SM-5688) ,the in vivo and in vitro test of Droxidopa (L-DOPS, SM-5688) ,the cell experiment of Droxidopa (L-DOPS, SM-5688) ,the IC50 and EC50 of Droxidopa (L-DOPS, SM-5688) please contact DC Chemicals.

CI994 (Tacedinaline) |cas 112522-64-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: CI994 (Tacedinaline)  ,cas 112522-64-2, Cat No. DC2060, In stock

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Product name: CI994 (Tacedinaline), Synonym:　PD-123654,CI-994,PD123654, Cat No. DC2060, Cas: 112522-64-2, Chemical Name:Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-, Molecular Formula: 112522-64-2, MW: 269.3

CI994 (Tacedinaline) Cas#112522-64-2.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM.

Description of Tacedinaline: Tacedinaline, also known as CI-944, is an orally bioavailable substituted benzamide derivative with potential antineoplastic activity. Tacedinaline inhibits histone deacetylation, which may result in histone hyperacetylation, followed by the induction of differentiation, the inhibition of cell proliferation, and apoptosis in susceptible tumor cell populations. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

For the detailed information about the solubility of CI994 (Tacedinaline)  in water, the solubility of CI994 (Tacedinaline)  in DMSO, the solubility of CI994 (Tacedinaline)  in PBS buffer, the animal experiment of CI994 (Tacedinaline) ,the in vivo and in vitro test of CI994 (Tacedinaline) ,the cell experiment of CI994 (Tacedinaline) ,the IC50 and EC50 of CI994 (Tacedinaline) please contact DC Chemicals.

A-803467 |cas 944261-79-4 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: A-803467 ,cas 944261-79-4, Cat No. DC2061, In stock

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Product name: A-803467, Synonym:　A803467, Cat No. DC2061, Cas: 944261-79-4, Chemical Name:5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide, Molecular Formula: C19H16ClNO4, MW: 357.79

A-803467 Cas#944261-79-4.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM.

A-803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

For the detailed information about the solubility of A-803467 in water, the solubility of A-803467 in DMSO, the solubility of A-803467 in PBS buffer, the animal experiment of A-803467,the in vivo and in vitro test of A-803467,the cell experiment of A-803467,the IC50 and EC50 of A-803467please contact DC Chemicals.

Ciproxifan (FUB-359) |cas 184025-18-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Ciproxifan (FUB-359) ,cas 184025-18-1, Cat No. DC2062, In stock

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Product name: Ciproxifan (FUB-359), Synonym:　FUB359, Cat No. DC2062, Cas: 184025-18-1, Chemical Name:1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-, Molecular Formula: C15H9Cl2NO2, MW: 306.14

Ciproxifan (FUB-359) Cas#184025-18-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Ciproxifan is an antagonists of H3-type histamine receptors.

Ciproxifan, Antagonists of H3-type histamine receptors exhibit cognitive-enhancing properties in various memory paradigms as well as evidence of antipsychotic activity in normal animals.Ciproxifan is an extremely potent histamine H3 inverse agonist/antagonist.Ciproxifan produces wakefulness and attentiveness in animal studies, and produced cognitive enhancing effects without prominent stimulant effects at relatively low levels of receptor occupancy, and pronounced wakefulness at higher doses.It has therefore been proposed as a potential treatment for sleep disorders such as narcolepsy and to improve vigilance in old age, particularly in the treatment of conditions such as Alzheimer's disease.It also potentiated the effects of antipsychotic drugs, and has been suggested as an adjuvant treatment for schizophrenia.

For the detailed information about the solubility of Ciproxifan (FUB-359) in water, the solubility of Ciproxifan (FUB-359) in DMSO, the solubility of Ciproxifan (FUB-359) in PBS buffer, the animal experiment of Ciproxifan (FUB-359),the in vivo and in vitro test of Ciproxifan (FUB-359),the cell experiment of Ciproxifan (FUB-359),the IC50 and EC50 of Ciproxifan (FUB-359)please contact DC Chemicals.

AG-L-59687 |cas 793035-88-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: AG-L-59687 ,cas 793035-88-8, Cat No. DC2063, In stock

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Product name: AG-L-59687, Synonym:　AGL-59687, Cat No. DC2063, Cas: 793035-88-8, Chemical Name:N/A, Molecular Formula: C24H34BrN5O7S, MW: 616.5

AG-L-59687 Cas#793035-88-8.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals!

For the detailed information about the solubility of AG-L-59687 in water, the solubility of AG-L-59687 in DMSO, the solubility of AG-L-59687 in PBS buffer, the animal experiment of AG-L-59687,the in vivo and in vitro test of AG-L-59687,the cell experiment of AG-L-59687,the IC50 and EC50 of AG-L-59687please contact DC Chemicals.

Apoptosis Activator 2 |cas 79183-19-0 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Apoptosis Activator 2   ,cas 79183-19-0, Cat No. DC2066, In stock

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Product name: Apoptosis Activator 2, Synonym:　N/A, Cat No. DC2066, Cas: 79183-19-0, Chemical Name:1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE, Molecular Formula: C15H9Cl2NO2, MW: 306.14

Apoptosis Activator 2 Cas#79183-19-0.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.

Apoptosis Activator 2 is a cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 μM for Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Apoptosis Activator 2 is an activator of caspase-3.

For the detailed information about the solubility of Apoptosis Activator 2   in water, the solubility of Apoptosis Activator 2   in DMSO, the solubility of Apoptosis Activator 2   in PBS buffer, the animal experiment of Apoptosis Activator 2  ,the in vivo and in vitro test of Apoptosis Activator 2  ,the cell experiment of Apoptosis Activator 2  ,the IC50 and EC50 of Apoptosis Activator 2  please contact DC Chemicals.

TDZD-8 |cas 327036-89-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: TDZD-8 ,cas 327036-89-5, Cat No. DC2067, In stock

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Product name: TDZD-8, Synonym:　TDZD8, TDZD 8, Cat No. DC2067, Cas: 327036-89-5, Chemical Name:1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-, Molecular Formula: C10H10N2O2S, MW: 222.26

TDZD-8 Cas#327036-89-5.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM.

Description of TDZD-8: TDZD-8 is a serine/threonine glycogen synthase kinase 3beta (GSK-3beta) inhibitor. GSK-3beta is abundant in the central nervous system, particularly in the hippocampus, and plays a pivotal role in the pathophysiology of a number of diseases, including neurodegeneration. TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. TDZD-8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes. Treatment of glioblastoma stem cells with TDZD-8 resulted in an inhibition of proliferation and self-renewal of these cells.

For the detailed information about the solubility of TDZD-8 in water, the solubility of TDZD-8 in DMSO, the solubility of TDZD-8 in PBS buffer, the animal experiment of TDZD-8,the in vivo and in vitro test of TDZD-8,the cell experiment of TDZD-8,the IC50 and EC50 of TDZD-8please contact DC Chemicals.

R547 |cas 741713-40-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: R547 ,cas 741713-40-6, Cat No. DC2068, In stock

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Product name: R547, Synonym:　R-547, R 547, Cat No. DC2068, Cas: 741713-40-6, Chemical Name:(4-amino-2-(1-(methylsulfonyl)piperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone, Molecular Formula: C18H21F2N5O4S, MW: 441Description of R547: R547 is orally bioavailable diaminopyrimidine cyclin-dependent kinase inhibitor (CDKI) with potential antineoplastic activity. CDKI R547 selectively binds to and inhibits CDKs, especially CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1. The inhibition of CDKs results in cell cycle arrest, inhibition of tumor cell proliferation, and induction of apoptosis. Through CDK inhibition, this agent also reduces phosphorylation of the retinoblastoma (Rb) protein, thus preventing activation of transcription factor E2F and so further suppressing tumor cell proliferation. CDKs are ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and are frequently overexpressed in tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

For the detailed information about the solubility of R547 in water, the solubility of R547 in DMSO, the solubility of R547 in PBS buffer, the animal experiment of R547,the in vivo and in vitro test of R547,the cell experiment of R547,the IC50 and EC50 of R547please contact DC Chemicals..45

R547 Cas#741713-40-6.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! R547 is a potent and selective CDK inhibitor with Ki and IC50 of 1-3 nM and 80 nM respectively.

GSK1904529A |cas 1089283-49-7 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: GSK1904529A ,cas 1089283-49-7, Cat No. DC2069, In stock

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Product name: GSK-1904529A, Synonym:　GSK1904529A, GSK 1904529A, Cat No. DC2069, Cas: 1089283-49-7, Chemical Name:N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenylamino)pyrimidin-4-yl)H-imidazo[1,2-a]pyridin-2-yl)-2-methoxybenzamide, Molecular Formula: C44H47F2N9O5S, MW: 851.96

GSK-1904529A Cas#1089283-49-7.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively.

GSK-1904529A is an IGF-1R Inhibitor, is is a promising candidate for therapeutic use in IGF-IR–dependent tumors. GSK1904529A selectively inhibits IGF-IR and IR with IC50s of 27 and 25 nmol/L, respectively. GSK1904529A blocks receptor autophosphorylation and downstream signaling, leading to cell cycle arrest. It inhibits the proliferation of cell lines derived from solid and hematologic malignancies, with multiple myeloma and Ewing's sarcoma cell lines being most sensitive. Oral administration of GSK1904529A decreases the growth of human tumor xenografts in mice, consistent with a reduction of IGF-IR phosphorylation in tumors. Despite the potent inhibitory activity of GSK1904529A on IR in vitro and in vivo, minimal effects on blood glucose levels are observed in animals at doses that show significant antitumor activity. (source: Clin Cancer Res May 1, 2009 15; 3058 )

For the detailed information about the solubility of GSK1904529A in water, the solubility of GSK1904529A in DMSO, the solubility of GSK1904529A in PBS buffer, the animal experiment of GSK1904529A,the in vivo and in vitro test of GSK1904529A,the cell experiment of GSK1904529A,the IC50 and EC50 of GSK1904529Aplease contact DC Chemicals.

GSK690693 |cas 937174-76-0 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: GSK690693 ,cas 937174-76-0, Cat No. DC2070, In stock

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Product name: GSK-690693, Synonym:　GSK690693, GSK 690693, Cat No. DC2070, Cas: 937174-76-0, Chemical Name:4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-((S)-piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol, Molecular Formula: C21H27N7O3, MW: 425.48

GSK-690693 Cas#937174-76-0.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively.

GSK690693 is a pan-AKT kinase inhibitor, is also an aminofurazan-derived inhibitor of Akt kinases with potential antineoplastic activity. Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

For the detailed information about the solubility of GSK690693 in water, the solubility of GSK690693 in DMSO, the solubility of GSK690693 in PBS buffer, the animal experiment of GSK690693,the in vivo and in vitro test of GSK690693,the cell experiment of GSK690693,the IC50 and EC50 of GSK690693please contact DC Chemicals.

ABR-215062 (Laquinimod) |cas 248281-84-7 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: ABR-215062 (Laquinimod) ,cas 248281-84-7, Cat No. DC2071, In stock

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Product name: ABR-215062 (Laquinimod), Synonym:　ABR215062, ABR 215062 (Laquinimod), Cat No. DC2071, Cas: 248281-84-7, Chemical Name:5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide, Molecular Formula: C19H17ClN2O3, MW: 356.8

ABR-215062 (Laquinimod) Cas#248281-84-7.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Laquinimod (ABR-215062) is a potent immunomodulator.

For the detailed information about the solubility of ABR-215062 (Laquinimod) in water, the solubility of ABR-215062 (Laquinimod) in DMSO, the solubility of ABR-215062 (Laquinimod) in PBS buffer, the animal experiment of ABR-215062 (Laquinimod),the in vivo and in vitro test of ABR-215062 (Laquinimod),the cell experiment of ABR-215062 (Laquinimod),the IC50 and EC50 of ABR-215062 (Laquinimod)please contact DC Chemicals.

LXR623|cas 875787-07-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: LXR623,cas 875787-07-8, Cat No. DC2072, In stock

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Product name: LXR623, Synonym:　LXR-623, LXR 623, Cat No. DC2072, Cas: 875787-07-8, Chemical Name:2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-, Molecular Formula: C21H12ClF5N2, MW: 422.778396

LXR623 Cas#875787-07-8.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! LXR-623 is a novel Liver X Receptor modulator

LXR-623, a novel Liver X Receptor modulator, displays neutral lipid effects in Cholesteryl Ester Transfer Protein-expressing species and inhibits atherosclerotic lesion progression in Low Density Lipoprotein receptor knockout miceFor the detailed information about the solubility of LXR623

 in water, the solubility of LXR623

 in DMSO, the solubility of LXR623

 in PBS buffer, the animal experiment of LXR623

,the in vivo and in vitro test of LXR623

,the cell experiment of LXR623

,the IC50 and EC50 of LXR623

please contact DC Chemicals.

17-AAG |cas 75747-14-7 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: 17-AAG ,cas 75747-14-7, Cat No. DC2073, In stock

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Product name: 17-AAG, Synonym:　17AAG, 17 AAG, Cat No. DC2073, Cas: 75747-14-7, Chemical Name:Geldanamycin, 17-demethoxy-17-(2-propenylamino)-, Molecular Formula: C31H43N3O8, MW: 585.69

17-AAG Cas#75747-14-7.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM.

Telatinib (17-AGG) is an orally bioavailable, small-molecule inhibitor of several receptor protein tyrosine kinases with potential antiangiogenic and antineoplastic activities. Telatinib binds to and inhibits the vascular endothelial growth factor receptors (VEGFRs) type 2 and 3, platelet-derived growth factor receptor beta (PDGFRb) and c-Kit, which may result in the inhibition of angiogenesis and cellular proliferation in tumors in which these receptors are upregulated. These telatinib-inhibited receptor protein tyrosine kinases are overexpressed or mutated in many tumor cell types and may play key roles in tumor angiogenesis and tumor cell proliferation. 17-AAG is a synthetic analogue of the benzoquinone ansamycin antibiotic geldanamycin and has also been found to inhibit the molecular chaperone Hsp90. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). 

For the detailed information about the solubility of 17-AAG in water, the solubility of 17-AAG in DMSO, the solubility of 17-AAG in PBS buffer, the animal experiment of 17-AAG,the in vivo and in vitro test of 17-AAG,the cell experiment of 17-AAG,the IC50 and EC50 of 17-AAGplease contact DC Chemicals.

17-DMAG (Alvespimycin) |cas 467214-20-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: 17-DMAG (Alvespimycin) ,cas 467214-20-6, Cat No. DC2074, In stock

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Product name: 17-DMAG (Alvespimycin), Synonym:　17DMAG, 17 DMAG, Cat No. DC2074, Cas: 467214-20-6, Chemical Name:N/A, Molecular Formula: C32H48N4O8.HCl, MW: 616.75

17-DMAG (Alvespimycin) Cas#467214-20-6.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) is a potent HSP90 inhibitor with IC50 of 62 nM.

Alvespimycin hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

For the detailed information about the solubility of 17-DMAG (Alvespimycin) in water, the solubility of 17-DMAG (Alvespimycin) in DMSO, the solubility of 17-DMAG (Alvespimycin) in PBS buffer, the animal experiment of 17-DMAG (Alvespimycin),the in vivo and in vitro test of 17-DMAG (Alvespimycin),the cell experiment of 17-DMAG (Alvespimycin),the IC50 and EC50 of 17-DMAG (Alvespimycin)please contact DC Chemicals.

Okadaic acid |cas 78111-17-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Okadaic acid   ,cas 78111-17-8, Cat No. DC2075, In stock

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Product name: Okadaic acid, Synonym:　N/A, Cat No. DC2075, Cas: 78111-17-8, Chemical Name:N/A, Molecular Formula: C44H68O13, MW: 805

Okadaic acid Cas#78111-17-8.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Okadaic Acid is a potent inhibitor of PP1 and PP2A phosphatases

Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, Prorocentrium spp.. It is a reversible, potent and selective inhibitor of two serine threonine protein phosphatases: PP2A-C (PP2A) which is inhibited completely at 1 nM and PP1 which is inhibited at higher concentrations (IC50= 10-15 nM). PP2B is much less sensitive to okadaic acid than PP1, while PP2C is not inhibited. This selectivity is the basis for an improved identification and quantification procedure for these enzymes. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. Okadaic Acid is an activator of PKC.

For the detailed information about the solubility of Okadaic acid   in water, the solubility of Okadaic acid   in DMSO, the solubility of Okadaic acid   in PBS buffer, the animal experiment of Okadaic acid  ,the in vivo and in vitro test of Okadaic acid  ,the cell experiment of Okadaic acid  ,the IC50 and EC50 of Okadaic acid  please contact DC Chemicals.

L-165041 |cas 79558-09-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: L-165041 ,cas 79558-09-1, Cat No. DC2076, In stock

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Product name: L-165041, Synonym:　L165041, L 165041, Cat No. DC2076, Cas: 79558-09-1, Chemical Name:N/A, Molecular Formula: C22H26O7, MW: 402.44

L-165041 Cas#79558-09-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! L-165041 is a potent PPARδ agonist (Ki = 6 nM)

L-165041 is a cell permeable peroxisome proliferator-activated receptor β (PPARβ) agonist which induces adipocyte differentiation in NIH-PPARβ cells. In addition, this ligand reduces lipid accumulation in the liver and decreases total hepatic cholesterol and triglyceride content. Studies suggest that L-165041 affects mRNA expression by reducing the expression of PPARγ, apolipoprotein B, interleukin 1 β (IL-1β), and interleukin-6, while increasing the expression of PPARβ, lipoprotein lipase (LPL), and ATP-binding cassette transporter G1 (ABCG1). Furthermore, upon binding to PPARβ L-165041 suppresses vascular smooth muscle proliferation and migration by inhibiting the cell cycle, specifically blocking G1 to S phase progression and repressing the phosphorylation of retinoblastoma protein (Rb) in rats. Alternate studies suggest that L-165041 suppresses the cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes.

For the detailed information about the solubility of L-165041 in water, the solubility of L-165041 in DMSO, the solubility of L-165041 in PBS buffer, the animal experiment of L-165041,the in vivo and in vitro test of L-165041,the cell experiment of L-165041,the IC50 and EC50 of L-165041please contact DC Chemicals.

JWH-133 |cas 259869-55-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: JWH-133 ,cas 259869-55-1, Cat No. DC2077, In stock

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Product name: JWH-133, Synonym:　JWH133, JWH 133, Cat No. DC2077, Cas: 259869-55-1, Chemical Name:(6AR,10AR)-3-(1,1-DIMETHYLBUTYL)-6A,7,10,10A-TETRAHYDRO-6,6,9-TRIMETHYL-6H-DIBENZO[B,D]PYRAN, Molecular Formula: C22H32O, MW: 312.49

JWH-133 Cas#259869-55-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! JWH-133 is a potent selective CB2 receptor agonist, with a Ki of 3.4nM and selectivity of around 200x for CB2 over CB1 receptors.

JWH-133 is a potent CB2 selective agonist (Ki = 3.4 nM). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis. Activity also enhances the release of IL-10 by LPS/IFN-γ-stimulated macrophages and results in downregulation of the IL-12 subunit p40. 

For the detailed information about the solubility of JWH-133 in water, the solubility of JWH-133 in DMSO, the solubility of JWH-133 in PBS buffer, the animal experiment of JWH-133,the in vivo and in vitro test of JWH-133,the cell experiment of JWH-133,the IC50 and EC50 of JWH-133please contact DC Chemicals.

GW-7647 |cas 265129-71-3 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: GW-7647 ,cas 265129-71-3, Cat No. DC2078, In stock

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Product name: GW-7647, Synonym:　GW7647, GW 7647, Cat No. DC2078, Cas: 265129-71-3, Chemical Name:N/A, Molecular Formula: C29H46N2O3S, MW: 502.75

GW-7647 Cas#265129-71-3.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! GW 7647 is a potent PPARα agonist with 200-fold selectivity over PPARγ and PPARδ.

GW 7647 is a potent PPARα agonist with 200-fold selectivity over PPARγ and PPARδ. This compound has also been found to cause an up-regulation of β-oxidation gene expression and an increase in palmitate oxidation. Additionally, glycolysis is strongly reduced at transcriptional levels by GW 7647 leading to a decrease in lactate and pyruvate production. Furthermore, this agent displays the ability to decrease glucose oxidation and inhibit lipogenesis and triglyceride esterification.

For the detailed information about the solubility of GW-7647 in water, the solubility of GW-7647 in DMSO, the solubility of GW-7647 in PBS buffer, the animal experiment of GW-7647,the in vivo and in vitro test of GW-7647,the cell experiment of GW-7647,the IC50 and EC50 of GW-7647please contact DC Chemicals.

GW-9662 |cas 22978-25-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: GW-9662 ,cas 22978-25-2, Cat No. DC2079, In stock

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Product name: GW-9662, Synonym:　GW9662, GW 9662, Cat No. DC2079, Cas: 22978-25-2, Chemical Name:Benzamide, 2-chloro-5-nitro-N-phenyl-, Molecular Formula: C13H9ClN2O3, MW: 276.68

GW-9662 Cas#22978-25-2.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! GW9662 is a selective PPAR antagonist, inhibiting PPARγ, PPARα and PPARδ with IC50 of 3.3 nM, 32 nM and 2 μM, respectively.

Description of GW9662: GW9662 is a potent, irreversible and selective PPARgamma antagonist, which prevented activation of PPARgamma and inhibited growth of human mammary tumour cell lines.

For the detailed information about the solubility of GW-9662 in water, the solubility of GW-9662 in DMSO, the solubility of GW-9662 in PBS buffer, the animal experiment of GW-9662,the in vivo and in vitro test of GW-9662,the cell experiment of GW-9662,the IC50 and EC50 of GW-9662please contact DC Chemicals.

TMS |cas 24144-92-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: TMS  ,cas 24144-92-1, Cat No. DC2080, In stock

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Product name: TMS, Synonym:　N/A, Cat No. DC2080, Cas: 24144-92-1, Chemical Name:N/A, Molecular Formula: C18H20O4, MW: 300.35

TMS Cas#24144-92-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.

CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.1 It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families.1 In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 ?g/ml.2

For the detailed information about the solubility of TMS  in water, the solubility of TMS  in DMSO, the solubility of TMS  in PBS buffer, the animal experiment of TMS ,the in vivo and in vitro test of TMS ,the cell experiment of TMS ,the IC50 and EC50 of TMS please contact DC Chemicals.

TPEN |cas 16858-02-9 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: TPEN  ,cas 16858-02-9, Cat No. DC2081, In stock

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Product name: TPEN, Synonym:　N/A, Cat No. DC2081, Cas: 16858-02-9, Chemical Name:N/A, Molecular Formula: C26H28N6, MW: 424.54

TPEN Cas#16858-02-9.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! TPEN is a cell permeable, high-affinity heavy metal (Zn2+>Fe2+>Mn2+) chelator that exhibits low affinity for Mg2+ and Ca2+.

TPEN is a cell permeable, high-affinity heavy metal (Zn2+>Fe2+>Mn2+) chelator that exhibits low affinity for Mg2+ and Ca2+. The compound is lipid-soluble and has been shown to permeate artificial and natural membranes. Research shows that TPEN induces apoptosis in human and rat thymocytes through DNA fragmentation and Caspace-3 activation. TPEN also induces mitochondrial cytochrome C translocation to the cytosol in human PBL. A recent study has proved this chelator to work in conjunction with the fluorescent probe Fura-2 (sc-202163) in biophysical studies of Ca2+.

For the detailed information about the solubility of TPEN  in water, the solubility of TPEN  in DMSO, the solubility of TPEN  in PBS buffer, the animal experiment of TPEN ,the in vivo and in vitro test of TPEN ,the cell experiment of TPEN ,the IC50 and EC50 of TPEN please contact DC Chemicals.

Monastrol |cas 329689-23-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Monastrol ,cas 329689-23-8, Cat No. DC2082, In stock

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Product name: Monastrol, Synonym:　N/A, Cat No. DC2082, Cas: 329689-23-8, Chemical Name:N/A, Molecular Formula: C14H16N2O3S, MW: 292.36

Monastrol Cas#329689-23-8.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Monastrol is a potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin.

Monastrol is a potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Monastrol arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 μM).

For the detailed information about the solubility of Monastrol in water, the solubility of Monastrol in DMSO, the solubility of Monastrol in PBS buffer, the animal experiment of Monastrol,the in vivo and in vitro test of Monastrol,the cell experiment of Monastrol,the IC50 and EC50 of Monastrolplease contact DC Chemicals.

PQ401 |cas 196868-63-0 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PQ401 ,cas 196868-63-0, Cat No. DC2083, In stock

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Product name: PQ401, Synonym:　PQ-401, PQ 401, Cat No. DC2083, Cas: 196868-63-0, Chemical Name:N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-, Molecular Formula: C18H16ClN3O2, MW: 341.79

PQ401 Cas#196868-63-0.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! PQ 401 is an IGF-1R inhibitor with IC50 of <1 μM.

PQ401 is a cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation. The mechanism of inhibition likely involves indirect blocking of ATP binding. PQ401 also decreases IGF-1R-dependent tumor cell growth in vitro.

For the detailed information about the solubility of PQ401 in water, the solubility of PQ401 in DMSO, the solubility of PQ401 in PBS buffer, the animal experiment of PQ401,the in vivo and in vitro test of PQ401,the cell experiment of PQ401,the IC50 and EC50 of PQ401please contact DC Chemicals.

Necrostatin-1 |cas 4311-88-0 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Necrostatin-1 ,cas 4311-88-0, Cat No. DC2084, In stock

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Product name: Necrostatin-1, Synonym:　Necrostatin1, Necrostatin 1, Cat No. DC2084, Cas: 4311-88-0, Chemical Name:4-Imidazolidinone, 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-, Molecular Formula: C13H13N3OS, MW: 259.33

Necrostatin-1 Cas#4311-88-0.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.

Necrostatin-1 is an inhibitor of necroptosis, a mechanism of programmed cell death separate from apoptosis. Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.

For the detailed information about the solubility of Necrostatin-1 in water, the solubility of Necrostatin-1 in DMSO, the solubility of Necrostatin-1 in PBS buffer, the animal experiment of Necrostatin-1,the in vivo and in vitro test of Necrostatin-1,the cell experiment of Necrostatin-1,the IC50 and EC50 of Necrostatin-1please contact DC Chemicals.