wp1066（STAT Inhibitor III）|DC Chemicals

wp1066（STAT Inhibitor III）|DC Chemicals

WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT.

Product name: wp1066（STAT Inhibitor III） |Cat No. DC8244|Other names: wp1066, wp 1066,wp-1066|Cas: 857064-38-1|Molecule Weight: 356.2|Molecule Formular: C17H14BrN3O| Purity: >98%

WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 µM.1 It also induces apoptosis in U87-MG (IC50 = 5.6 µM) and U373-MG (IC50 = 3.7 µM) cells.WP1066 is orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity, including immune activation as indicated by the up-regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats.

For research and scientific purpose only, not for human use.