KNK437|Pan hsp inhibitor|DC Chemicals

KNK437|Pan hsp inhibitor|DC Chemicals

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

Product name: KNK437 |Cat No. DC8247|Other names: KNK437,KNK 437|Cas: 218924-25-5|Molecule Weight: 245.23|Molecule Formular: C13H11NO4| Purity: >98%

KNK437 dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells.[1] KNK437 and quercetin inhibits thermotolerance in a dose-dependent manner in PC-3 cells. KNK437 decreases heat-induced accumulation of Hsp70 mRNA and protein in PC-3 and LNCaP cells.KNK437 (200 mg/kg, i.p.) shows no antitumor effects and does not increase the thermosensitivity of nontolerant tumors. The same dose of KNK437 enhances the antitumor effects of fractionated heat treatment in a synergistic manner.[

For research and scientific purpose only, not for human use.