Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.
Product name: Mps1-IN-2 |Cat No. DC8119|Other names: MPS1-IN2,MPS1-IN2|Cas: 1228817-38-6|Molecule Weight: 480.60244|Molecule Formular: C26H36N6O3| Purity: >98%
Mps1-IN-2 inhibited Mps1 kinase activity with half-maximal inhibitory concentrations (IC50) of 3145 nM when screened at 1 μM ATP (apparent Km for ATP < 1 μM). Both compounds demonstrated greater than 1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk for Mps1-IN-1 and Gak and Plk1 for Mps1-IN-2. The M602Q Mps1 mutant was 5 and 19-fold less sensitive to Mps1-IN-1 and Mps1-IN-2 respectively.
For research and scientific purpose only, not for human use.
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