PIK-93|PI4K (PI4KIIIβ) inhibitor|DC Chemicals

PIK-93|PI4K (PI4KIIIβ) inhibitor|DC Chemicals

PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.

Product name: PIK-93 |Cat No. DC8254|Other names: PIK-93,PIK 93,PIK93 |Cas: 593960-11-3|Molecule Weight: 389.88|Molecule Formular: C14H16ClN3O4S2| Purity: >98%

PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.PIK-93 is a PI4KIIIβ inhibitor (IC50 at 19 nM). PIK-93 is the first reported PI4-kinase inhibitor, which is able to inhibit PI4KIIIβ at low-nanomolar range. In addition, PIK-93 also inhibits potently PI3Kγ in vitro (IC50 at 16 nM). PIK-93 inhibits p110α, p110β, p110δwith IC50 of 0.039, 0.59, 0.12 μM. PIK-93 also displays the typical hydrogen bonding to the backbone amide of  Val882, and additional ones to the backbone carbonyl of Val882 and between its sulphonamide and Asp964.

For research and scientific purpose only, not for human use.