PLX3397 (Pexidartinib)|CSF1 inhibitor|DC Chemicals

PLX3397 (Pexidartinib)|CSF1 inhibitor|DC Chemicals

PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS.

Product name: Pexidartinib(PLX3397) |Cat No. DC8158|Other names: PLX3397,PLX 3397,PLX-3397,Pexidartinib|Cas: 1029044-16-3|Molecule Weight: 417.81|Molecule Formular: C20H15ClF3N5| Purity: >98%

In the study, 23 patients with advanced PVNS in a single joint received 1000 mg of PLX3397 orally each day. Patients underwent an MRI every two months to measure tumor volume using a novel tumor volume score developed for PVNS. Among the 14 patients with evaluable MRI scans, the mean tumor size reduction was 61 percent. Eleven patients experienced a partial response (at least a 50 percent decrease in tumor volume compared to baseline screenings) and three had stable disease. Patients remained on the drug until disease progression or intolerability.

For research and scientific purpose only, not for human use.