Pilaralisib(XL-147; SAR245408)|Supplied by DC Chemicals

Pilaralisib(XL-147; SAR245408)|Supplied by DC Chemicals

Pilaralisib (SAR245408; XL147) is selective oral pan-PI3K inhibitor.

Product name: Pilaralisib(XL-147; SAR245408) |Cat No. DC8184|Other names: Pilaralisib, XL-147; SAR245408|Cas: 934526-89-3|Molecule Weight: 540.13|Molecule Formular: C25H25ClN6O4S| Purity: >98%

Pilaralisib, also known as XL147, is a Class 1 PI3K kinase family inhibitor, and  is an orally bioavailable small molecule, targeting the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Class 1 PI3K kinase family inhibitor XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents including genotoxic agents and receptor tyrosine kinase inhibitors.

For research and scientific purpose only, not for human use.