TP-0903|Axl kinase inhibitor|DC Chemicals

TP-0903|Axl kinase inhibitor|DC Chemicals

TP-0903 is a a high-affinity Axl inhibitor with IC50 of 27 nM.

Product name: TP-0903 |Cat No. DC8223|Other names: TP-0903 ,TP0903 , TP-0903 |Cas: 1341200-45-0|Molecule Weight: 516.06|Molecule Formular: C24H30ClN7O2S| Purity: >98%

TP-0903 induces massive apoptosis in CLL B cells with LD50 values of nanomolar ranges. Importantly, CLL BMSCs could not protect the leukemic B cells from TP-0903-induced apoptosis. A marked reduction of the antiapoptotic proteins Mcl-1, Bcl-2, and XIAP and upregulation of the proapoptotic protein BIM in CLL B cells was detected as a result of Axl inhibition. Finally, combination of TP-0903 with BTK inhibitors augments CLL B-cell apoptosis.Administration of TP-0903 either as a single agent or in combination with BTK inhibitors may be effective in treating patients with CLL.

For research and scientific purpose only, not for human use.