GMX1778(CHS-828，CHS828）|DC Chemicals

GMX1778(CHS-828，CHS828）|DC Chemicals
CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.

Product name: GMX1778(CHS-828)  |Cat No. DC8139|Other names: CHS-828,CHS828,CHS 828|Cas: 200484-11-3|Molecule Weight: 371.87|Molecule Formular: C19H22ClN5O| Purity: >98%

CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitro and in vivo.In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.

For research and scientific purpose only, not for human use.