YO-01027(Dibenzazepine)|γ secretase inhibitor|DC Chemicals

YO-01027(Dibenzazepine)|γ secretase inhibitor|DC Chemicals

YO-01027 (Dibenzazepine, DBZ) is a dipeptidic g-secretase inhibitor with IC50 of 2.6 and 2.9 nM for APPL and Notch, respectively.

Product name: YO-01027(Dibenzazepine)  |Cat No. DC8217|Other names: YO-01027(Dibenzazepine) |Cas: 209984-56-5|Molecule Weight: 463.48|Molecule Formular: C26H23F2N3O3| Purity: >98%

YO-01027 (Dibenzazepine, DBZ) is a dipeptidic g-secretase inhibitor with IC50 of 2.6 and 2.9 nM for APPL and Notch, respectively. YO-01027 targets the Presenilin fragment. Increasing concentrations of YO-01027 administered to APPl- or Notch-expressing cells leads to the progressive accumulation of APPL C-terminal fragments and a decrease in NICD production in a dose-dependent manner.
In an in vitro model of human corneal and conjunctival epithelial cell differentation, YO-01027 impaired MUC16 biosynthesis in a concentration-dependent manner.
In oncology models, YO-01027 preferentially inhibited Notch and significantly decreased MCF7 tumors and increased latency compared with control mice.

For research and scientific purpose only, not for human use.